Late-stage diversification of peptidomimetics and oligopeptides via gold-catalyzed post-Ugi cyclization
نویسندگان
چکیده
A chemo- and regioselective gold-catalyzed tandem 6-endo-dig cyclization/enyne cycloisomerization/1,2-migration process for the synthesis of decorated peptidomimetics is developed. Various migrating groups such as aryl, heteroaryl alkyl are tolerated in this method under mild conditions. This protocol successfully utilized to modify various oligopeptides, including substrates bearing drug amantadine, a rapid step-economical manner through combination with Ugi reaction.
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ژورنال
عنوان ژورنال: Molecular Catalysis
سال: 2022
ISSN: ['2522-5081', '2522-509X']
DOI: https://doi.org/10.1016/j.mcat.2022.112240